Write 5 pages thesis on the topic advanced genetic analysis review. The example of the lin-18 genes, when combined with mom-2, suggests that the probability .will be less than 10%. Neither of the genes yields probabilities equal to 10% or even greater than 1%, there is no data that indicates a higher percentage. These mutations are likely to be hypomorphic, as they lower the probability of expression.
It is probable that during embryonic development, there are two separate stages in which .lin-44 and mom-2 are activated leading to a protein that completes a quaternary structure involving the lin-17 and lin-18 membrane proteins. The lack of 44 and mom leads to a protein conformation error resulting in the bi-vulva condition. The available data implies a developmental process in which lin-17 and 18 are transcribed into proteins localized to the membranes, but their natural conformation depends upon the secretory gene-products of lin-44 and mom 2.
One possible test for this idea would likely be a form of X-ray crystallography to elucidate the structure produced by expression of lin-17 and lin-18, and then to match the structures with the products of 44 and mom. This theory would predict the combination of all these gene products resulting in a single quaternary structure. If no stable structure can be elucidated, or if the secretory products themselves formed a quaternary structure, this would contradict the model.
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Reporter gene mom-2 has a signaling function that effects lin-18, but mom-1 does not, as it does not affect the VPC-4 cell. It is possible that mom-2 .assumes control of the maturation process begun in larval stage one by lin-18, . and its function is distinct from mom-1.